CSV Bulk calculations specifications: COR

This type of CSV allows to get, for each row, adjusted scores according to corticosteroid dose.

Adjusting conventional FRAX estimates of fracture probability according to corticosteroid dose (only available if glucocorticoids is yes). These adjustments are based on the assumption that the average dose used by those subjects recruited to the FRAX development cohorts lay within the range of 2.5-7.5mg daily prednisolone (or equivalent). The adjustments were derived from a single study using the GPRD database in the UK.

Input Variables

A CSV input file should always have 14 columns. An optional header can be sent as first line of the CSV file:

Score unit,Country,Age,Sex,BMI,Previous fracture,Parental history,Current smoker,Gluccocorticoid,Rheumatoid Arthritis,Secondary osteoporosis,Alcohol,Femoral neck BMD,dose

The first columns are the FRAX variables:

#	Col	Variable	Description	Possible Values
1	A	Score unit	Unit for variable 13	t: T-score, z: Z-score. Unit for parameter 13 (BMD) described below.
2	B	Country	Code for country and ethnicity	Integer. Get valid countries' id from the API.
3	C	Age	Age in years	Positive real number (40-90), can have decimals. Out of bound values will be capped.
4	D	Sex	Gender	0: men, 1: women
5	E	BMI	Body Mass Index	Positive real number (kg/m²), can have decimals
6	F	Previous fracture	History of previous fracture	0: no, 1: yes
7	G	Parental history	Parent(s) with hip fracture history	0: no, 1: yes
8	H	Current smoker	Current smoking status	0: no, 1: yes
9	I	Gluccocorticoid	Gluccocorticoid use	0: no, 1: yes
10	J	Rheumatoid Arthritis	Presence of rheumatoid arthritis	0: no, 1: yes
11	K	Secondary osteoporosis	Presence of secondary osteoporosis	0: no, 1: yes
12	L	Alcohol	More than two drinks a day	0: no, 1: yes
13	M	Femoral neck BMD	Bone mineral density measurement	Real number (T-score or Z-score). The T-score for both genders should be derived by comparing the individual BMD to the young normal FEMALE NHANES III reference range for the make of scanner that you are using.

Then we need the adjustment variable:

#	Col	Variable	Description	Possible Values
14	N	dose	Daily corticosteroid dose	HIG High dose of corticosteroid ≥7.5 mg/day, MID dose above 2.5 and under 7.5 mg/day (no adjustment needed), LOW low dose of corticosteroid <2.5mg/day

Output Results

Once processed, you will receive an output file with, for each row, the results append to the original line (the variables above).

#	Col	Result	Description
15	O	COR MOF wo BMD	Adjusted MOF without BMD according to dose of corticosteroid
16	P	COR Hip wo BMD	Adjusted HIP without BMD according to dose of corticosteroid
17	Q	COR MOF w BMD	Adjusted MOF with BMD according to dose of corticosteroid
18	R	COR Hip w BMD	Adjusted HIP with BMD according to dose of corticosteroid

Output warning or error reporting

If an error for any adjustments of the row has been triggered, a specific message will be added at the end of the line.

#	Col	Processor messages
19	S	Warning or error messages